As is so often the case for Peter Parker (Tom Holland), he's winds up being the architect of his own misery. To undo the chaos caused in his life after his identity as Spider-Man is revealed at the end of 2019's Spider-Man: Far From Home, Peter seeks the help of Doctor Strange (Benedict Cumberbatch). But his indecision instead cracks open the multiverse and unleashes a suite of villains from previous Spider-Man franchises, including Willem Dafoe's Green Goblin from 2002's Spider-Man, Alfred Molina's Otto Octavius from 2004's Spider-Man 2, Thomas Haden Church's Sandman from 2007's Spider-Man 3, Rhys Ifans' the Lizard from 2012's The Amazing Spider-Man, and Jamie Foxx's Electro from 2014's The Amazing Spider-Man 2.
The presence of so many villains from previous iterations of Spider-Man has led fans to expect that the actors who played the web-singer – Tobey Maguire and Andrew Garfield – to show up as well. But while the trailer confirmed that Molina's Doc Ock does not consider Holland to be Peter Parker, Maguire and Garfield were nowhere to be seen.