Dr Wirenfeldt Nielsen reaches for a box amidst the world's largest collection of preserved brains from deceased mental health patients in the basement of the University of Southern Denmark. — AFP
Countless shelves line the walls of a basement at the University of Southern Denmark, holding what is thought to be the world's largest collection of brains.
There are 9,479 of the organs, all removed from the corpses of mental health patients over the course of four decades until the 1980s.
Preserved in formalin in large white buckets labelled with numbers, the collection was the life's work of prominent Danish psychiatrist Dr Erik Stromgren.
Begun in 1945, it was a "kind of experimental research," Jesper Vaczy Kragh, an expert in the history of psychiatry, explains.
Dr Stromgren and his colleagues believed "maybe they could find out something about where mental illnesses were localised, or they thought they might find the answers in those brains".
No permission asked
The brains were collected after autopsies had been conducted on the bodies of people committed to psychiatric institutes across Denmark.Neither the deceased nor their families were ever asked permission.
"These were state mental hospitals and there were no people from the outside who were asking questions about what went on in these state institutions," Vaczy Kragh says.
At the time, patients' rights were not a primary concern.
On the contrary, society believed it needed to be protected from these people, the researcher from the University of Copenhagen says.
Between 1929 and 1967, the law required people committed to mental institutions to be sterilised.
Up until 1989, they had to get a special exemption in order to be allowed to marry.
Denmark considered "mentally ill" people, as they were called at the time, "a burden to society (and believed that) if we let them have children, if we let them loose... they will cause all kinds of trouble," he says.
Back then, every Dane who died was autopsied, says pathologist and the collection's director Dr Martin Wirenfeldt Nielsen.
"It was just part of the culture back then, an autopsy was just another hospital procedure," he says.
The evolution of post-mortem procedures and growing awareness of patients' rights heralded the end of new additions to the collection in 1982.
A long and heated debate then ensued on what to do with it.
Denmark's state ethics council ultimately ruled that it should be preserved and used for scientific research.
An invaluable resource
The collection, long housed in Aarhus in western Denmark, was moved to Odense where the University of Southern Denmark is located, in 2018.Research on the collection has over the years covered a wide range of illnesses, including dementia, schizophrenia, bipolar disorder and depression.
"The debate has basically settled down, and (now people) say 'okay, this is very impressive and useful scientific research if you want to know more about mental disease'," Dr Wirenfeldt Nielsen says.
Some of the brains belonged to people who suffered from both mental health issues and brain illnesses.
"Because many of these patients were admitted for maybe half their life, or even their entire life, they would also have had other brain diseases, such as a stroke, epilepsy or brain tumours," he adds.
Four research projects are currently using the collection.
"If it's not used, it does no good," says the former head of Denmark's mental health association, Knud Kristensen.
"Now we have it, we should actually use it," he says, complaining about a lack of resources to fund research.
Neurobiologist Dr Susana Aznar, a Parkinson's expert working at a Copenhagen research hospital, is using the collection as part of her team's research project.
She says the brains are unique in that they enable scientists to see the effects of modern treatments.
"They were not treated with the treatments that we have now," she says.
The brains of patients nowadays may have been altered by the treatments they have received.
When Dr Aznar's team compares these with the brains from the collection, "we can see whether these changes could be associated with the treatments," she says. – AFP Relaxnews
