Scientists hope that a new daily contraceptive pill for men, currently being trialled in the UK, could take the burden off women in the prevention of unplanned pregnancies. — dpa
A group of men in the United Kingdom are the first in the world to test a new hormone-free male contraceptive pill.
Scientists hope that if the tests are successful, the daily pill could broaden shared responsibility for contraception between the sexes.
Men can currently only use condoms or have a vasectomy, in contrast to the vast array of contraceptives for women, including the pill, the coil, a contraceptive injection, and use of diaphragms or female condoms, among other options.
The new male pill is a hormone-free drug, unlike the female pill.
The pill, YCT-529, is a drug called a retinoic acid receptor-alpha inhibitor, which prevents sperm production by blocking access to vitamin A.
Previous studies dating back more than 90 years have shown that depriving mice, rats and monkeys of vitamin A can cause infertility.
Experts from the American biopharmaceutical company YourChoice Therapeutics said that pre-clinical studies showed YCT-529 was “99% effective and 100% reversible with no side effects”.
The company said that previous versions of the male pill have attempted to suppress the male sex hormone testosterone to prevent
sperm production, but this does not stop sperm production completely and has been linked to some complications.
Now, 16 men are testing the hormone-free pill in the UK.
The phase 1 clinical trial is being conducted by Quotient Sciences, a drug development company based in the English city of Nottingham.
”The last innovation in contraception was the birth control pill for women, and that’s more than 60 years ago,” said University of Minnesota College of Pharmacy Regents Professor Dr Gunda Georg, who developed the pill.
”The world is ready for a male contraceptive agent, and delivering one that’s hormone-free is simply the right thing to do given what we know about the side effects women have endured for decades from the pill,” she said.
”We consciously chose to inhibit the vitamin A signalling pathway in the testis because nearly 100 years of research has validated this
pathway and shows that infertility can be reversed easily,” she added.
”Our pre-clinical data is strong, showing that YCT-529 was 99% effective in preventing mouse pregnancies and decreasing monkey sperm counts after two weeks of dosing.
"YCT-529 has also demonstrated a strong safety profile, and full reversibility in mice and monkeys once treatment ended.”
YourChoice Therapeutics co-founder and chief executive of Akash Bakshi noted that the drug blocks a protein – not hormones – to
prevent sperm production.
”We believe this will be more attractive to men, most of whom view pregnancy prevention as a shared responsibility, even despite today’s limited contraceptive options, which are permanent or only moderately effective,” he said.
”The dearth of options reinforces the centuries-old view that pregnancy prevention is ‘a woman’s responsibility’.
"It’s not, and we’re committed to advancing the first hormone-free birth control pill for men that’s effective, convenient and temporary.” – PA Media/dpa
