When stool remains too long in the gut, they start producing toxic proteins, rather than beneficial fatty acids. — Filepic
Everybody poops sometimes, but does it really matter how often?
A new study published July 16 (2024) in the journal Cell Reports Medicine reveals that bowel movement frequency significantly influences physiology and long-term health, with the best outcomes linked with passing stools once or twice a day.
Previous research has suggested associations between constipation and diarrhoea with higher risks of infections and neurodegenerative conditions respectively.
But since these findings were observed in sick patients, it remained unclear whether irregular bathroom visits were the cause or result of their conditions.
“I do hope that this work will kind of open clinicians’ minds a bit to the potential risks of not managing bowel movement frequencies,” study senior author and US-based Institute for Systems Biology associate professor Dr Sean Gibbons said.
The microbiome researcher explained that doctors often view irregular movements as merely a “nuisance”.
Assoc Prof Gibbons and his team collected clinical, lifestyle and biological data – including blood chemistry, gut microbiome, genetics and more – from over 1,400 healthy adult volunteers with no signs of active disease.
Participants’ self-reported bowel movement frequencies were categorised into four groups:
- Constipation (one or two bowel movements per week)
- Low-normal (three to six per week)
- High-normal (one to three per day), and
- Diarrhoea.
When stools linger too long in the gut, microbes exhaust the available fibre – which they ferment into beneficial short-chain fatty acids – and instead ferment proteins, producing toxins like p-cresol sulphate and indoxyl sulphate.
“What we found is that even in healthy people who are constipated, there is a rise in these toxins in the bloodstream,” said Assoc Prof Gibbons, noting that these toxins are particularly burdensome to the kidneys.
In cases of diarrhoea, the team found clinical chemistries indicative of inflammation and liver damage.
Assoc Prof Gibbons explained that during diarrhoea, the body excretes excessive bile acid, which the liver would otherwise recycle to dissolve and absorb dietary fats.
Fibre-fermenting gut bacteria known as “strict anaerobes”, which are associated with good health, thrived in the “Goldilocks Zone” of one or two poops a day.
However, he emphasised that more research is needed to define this optimal range more precisely.
Demographically, younger people, women and those with a lower body mass index (BMI), tended to have less frequent bowel movements.
Hormonal and neurological differences between men and women may explain the gap, he said, along with the fact that men generally consume more food.
Finally, by pairing biological data with lifestyle questionnaires, the team painted a clear picture of those who typically fall into the Goldilocks Zone.
“It was eating more fruit and vegetables – that was the biggest signal we saw,” said Assoc Prof Gibbons, along with drinking plenty of water, regular physical activity and eating a more plant-dominant diet.
The next step in the research could involve designing a clinical trial to manage the bowel movements of a large group of people, followed over an extended period to assess its potential in disease prevention. – AFP Relaxnews
