The GLP-1 workout: Targeting the muscle loss from taking these drugs


By AGENCY

Kimani guides Bunge through a lat pull down during a GLP-1–specific workout, which focuses on building strength from back and lower body muscle loss. — TNS

It's 10am on a Friday at Surfcore Fitness, a boutique gym in Mid-City, Los Angeles in the United States, and a 52-year-old woman is following an exercise circuit as her trainer watches on.

The fashion consultant, who is squeezing in a session before work, lifts relatively light weights while doing simple movements to build strength: goblet squats with a 6lb (2.7kg) kettlebell, then bicep curls with a 10lb (4.5kg) weight.

You’d never guess it, but this is the latest exercise craze in action: Call it the GLP-1 workout.

GLP-1 drugs such as semaglutide and tirzepatide have helped millions of people combat Type 2 diabetes and cardiovascular (heart) disease, as well as shed weight.

The class of drugs – GLP-1 receptor agonists – has been around for two decades as a diabetes medication.

Their popularity as a tool for weight loss skyrocketed after the US Food and Drug Administration (FDA) approved semaglutide for weight management in 2021.

But these drugs have also created new challenges.

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The weight loss they spur often comes with a reduction in lean body mass that includes muscle, making people physically weaker.

Because GLP-1 drugs send signals to the brain telling people to feel full on fewer calories, those taking them are often operating in a caloric deficit.

That reduced appetite, if not overseen properly by a doctor, could cause nutritional deficiencies and leave people with less energy for workouts, says Cedars-Sinai Medical Center preventive cardiology director Dr Martha Gulati.

It’s then harder to exercise at the intensity needed to gain back the muscle they’ve been losing.

“Depending on the drug, people can lose between 25%-50% of their lean body mass,” Dr Gulati says.

Which is where the GLP-1 workout comes in.

The routine’s aim is to help patients build and preserve muscle mass by prioritising strength training over cardio.

It often incorporates education around nutrition and post-workout recovery techniques, helping participants develop new, healthy lifestyle habits to prevent weight gain once they go off the GLP-1 drugs.

Jumping on the trend

Over the last year (2024), the hashtags #ozempicworkout and #glp1training have populated TikTok and Instagram, and the GLP-1 workout has been ­promoted at gyms, on blogs and on the YouTube accounts of ­personal trainers.

American luxury fitness chain Equinox introduced a “GLP-1 protocol” in January 2024 and has since rolled it out at 80 clubs internationally.

American gym franchisor and operator Planet Fitness posts GLP-1 workout guidelines on its blog.

Independent gyms in Los Angeles, such as Surfcore Fitness, are promoting GLP-1 workouts on Instagram “to stay ahead of the curve”, says owner Carlos Sosa.

Personal trainers are getting in on the trend as well.

American exercise influencer and trainer Chris Ryan debuted a GLP-1 workout series on his fitness app this month (March 2025) that includes live and on-demand routines.

“If fitness professionals don’t tailor their approach to individuals on these medications, then there are risks for (them) losing functional strength, bone ­density, metabolic health,” says Minneapolis-based Fitness Business Association chief ­executive officer Josh Leve.

“So we’re seeing a pretty rapid response from the industry to offset these dangers.”

The beginner’s strength-­training regime isn’t new.

Rather, it’s been repackaged for a new fitness audience.

“It’s just marketing,” says University of South Carolina department of exercise science chair Professor Dr Shawn M. Arent.

“We might have to take into account a lack of energy (on the part of GLP-1 exercisers).

“But in terms of our general guidelines for resistance training, there really is nothing special about a GLP-1 workout.

“At the end of the day, it’s just resistance training.

“But that’s not sexy.”

Regardless, the routine appears to be here to stay.

About 6% of adults in the US say they are taking GLP-1 drugs for weight loss, according to a 2024 poll conducted by the San Francisco-based health policy non-profit organisation KFF.

That’s more than 15 million people.

With these branded workouts, American fitness facilities and trainers are courting a new class of consumers.

The trend has had a ripple effect on organisations that administer certification programmes for fitness trainers.

The US National Academy of Sports Medicine and the American Council on Exercise are now offering GLP-1 education.

The US National Exercise & Sports Trainers Association (Nesta) debuted a “GLP-1 Exercise Specialist Certificate” in January (2025) that it touts as a “passport to success” for trainers.

Different priorities

Regardless of whether these GLP-1 workouts are innovative, promoting these exercises helps to build community among those who are using the drugs, says exercise physiologist Eric Durak, who authored Nesta’s GLP-1 certificate programme.

“It’s about changing the mindset and lifestyle of overweight people, many of whom have never exercised before,” he says.

“Some may be people who didn’t feel accepted by society because they weighed more than 300lb (136kg).

“We want to get them in the door, then create a space for them that they feel is more a community than a training ­centre.

“The trainer’s job goes above sets and reps with this population.

“It’s also about developing relationships.”

Gyms and trainers are approaching the GLP-1 workout with different priorities in mind.

Some focus on educating ­clients about nutrition, advising they eat more protein and ­monitor macronutrients.

Others emphasise post-workout recovery strategies, like guided stretching, sleep optimisation and tracking tools to monitor muscle-mass retention.

Equinox’s GLP-1 protocol is considered a framework for people taking the drugs – one that addresses workout intensity, frequency and volume (how many reps), as well as robust habit coaching, says the club’s senior personal training manager Stan Ward.

“When they’re getting these workouts in, we’re also talking about their lifestyle,” he says.

“Whole food sources, portion sizes – we help them navigate food and understand when they feel full.

“And how to do that in a long-term, sustainable fashion.”

At Surfcore Fitness, Sosa is in touch directly with clients’ ­doctors, he says.

“Doctors are sending people here: ‘I’m not gonna give you the (GLP-1) drug unless you workout,’ they tell them.

“So I talk with their doctor about what their needs are, the specific drugs they’re on and the dosage, any side effects, plus any other health concerns,” he shares.

“I reassure them my workouts will address their needs.”

Focusing on needs

One of Sosa’s clients, the 52-year-old fashion consultant, went on tirzepatide last March (2024) and has since lost 40lb (18kg), but she saw muscle on her triceps and legs dwindle.

The GLP-1 workout has helped her body composition, Sosa says, and his being in touch with her doctor has given her confidence.

“She feels comfortable to be working out with me specifically, because I know what her needs are medically,” he says.

The GLP-1 training regime at the LA Athletic Club (LAAC) is particularly focused on the side effects of the medications, and then tailoring workouts to mitigate them.

It partnered with the San Diego County-based CHEK Institute, to0 hold workshops for trainers.

They’re now careful not to overexert clients or to quickly switch up exercises from sitting to standing positions because high doses of GLP-1 drugs can cause dizziness.

Longer and more intense workouts may cause increased gastrointestinal issues, like nausea and stomach discomfort, so trainers focus on consistent, moderately intense workouts.

“The last thing we want to do is push them too hard,” says LAAC director Ed Gemdjian.

“We want to work them to their comfort level, and then continue that consistency.”

Independent trainer Mike Kimani says his GLP-1 workouts are particularly data-driven.

“The whole workout is choreographed and timed to a T, customised to where they’re losing muscle,” he says.

He requires clients on GLP-1 drugs to get body scans every two to four weeks.

“It’s so we’re not just guessing. We’re feeling good, but what does that mean, data-wise?

“We’re looking to track muscle growth,” he says.

His client, Jessica Bunge, 37, went on semaglutide last June (2024) for diabetes.

She’d never been a serious exerciser – the gym was “an intimidating place,” she says.

But she lost more than 30lb (13.6kg) on the drug, which has been a game-changer.

“I no longer feel, ‘Oh, my gosh, is everyone looking at my body?’ I feel more confident here now,” she says.

“I train twice a week, and it’s helped everything massively.

“I definitely feel stronger, even just running up the stairs.”

Perspectives on the GLP-1 workout may vary, but the trainers interviewed for this story stressed that one thing is key: strength training to counter muscle loss from the drugs.

“Ultimately, we’re looking for people to create new healthy habits and improve their lives,” says Leve.

“It’s gotta start somewhere.” – By Deborah Vankin/Los Angeles Times/Tribune News Service

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Weight loss , muscles , exercise , workout , drugs

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