Scientists develop new cancer treatment based on engineered antibody


JERUSALEM, Jan. 18 (Xinhua) -- Israeli scientists developed a new antibody that creates a powerful immune response against cancer, Israel's Weizmann Institute of Science (WIS) said in a statement on Thursday.

This new immunotherapeutic development, described in a study published in the journal Cell, improves communication between immune cells and may lead to innovative therapies for cancer and autoimmune diseases, the WIS said.

The researchers discovered that immune T cells become exhausted and lose their effectiveness in fighting cancerous tumors without the stimulatory support of dendritic immune cells.

Consequently, common immunotherapy treatments are ineffective in many patients because their tumor areas lack dendritic immune cells, while in other patients effectiveness is short-lived.

The team then engineered the two-armed antibody, named BiCE (Bispecific DC-T Cell Engager), with one arm blocking the harmful receptor that exhausts the T cells, while the other arm recruits the essential dendritic cell.

In mouse experiments, the researchers found that the antibody slowed the growth of tumors in lung, skin, and breast cancers.

Furthermore, it was discovered that the new antibody can prevent a future outbreak of cancer, by leaving behind immune cells that remember how to identify cancer and respond accordingly.

Follow us on our official WhatsApp channel for breaking news alerts and key updates!
   

Next In World

In her Indian grandfather's village, residents pray for Kamala Harris win
Erdogan ally floats Turkey constitutional amendment to let him extend his tenure
Irish PM to call general election this week
Kremlin says Moldovan election was unfair, questions Sandu's legitimacy
Swiss police catch more than a dozen drug traffickers in Verbier bust
Poland to spend $750 million to boost ammunition production
Apple explores push into smart glasses with ‘Atlas’ user study
Hacker gets into woman’s email, changes every password, tries to make purchases
Exclusive-India aims to curb judges' arbitrary sentences for criminals, sources say
Want to help a friend find love? Give a PowerPoint presentation

Others Also Read