Scientists develop new cancer treatment based on engineered antibody


JERUSALEM, Jan. 18 (Xinhua) -- Israeli scientists developed a new antibody that creates a powerful immune response against cancer, Israel's Weizmann Institute of Science (WIS) said in a statement on Thursday.

This new immunotherapeutic development, described in a study published in the journal Cell, improves communication between immune cells and may lead to innovative therapies for cancer and autoimmune diseases, the WIS said.

The researchers discovered that immune T cells become exhausted and lose their effectiveness in fighting cancerous tumors without the stimulatory support of dendritic immune cells.

Consequently, common immunotherapy treatments are ineffective in many patients because their tumor areas lack dendritic immune cells, while in other patients effectiveness is short-lived.

The team then engineered the two-armed antibody, named BiCE (Bispecific DC-T Cell Engager), with one arm blocking the harmful receptor that exhausts the T cells, while the other arm recruits the essential dendritic cell.

In mouse experiments, the researchers found that the antibody slowed the growth of tumors in lung, skin, and breast cancers.

Furthermore, it was discovered that the new antibody can prevent a future outbreak of cancer, by leaving behind immune cells that remember how to identify cancer and respond accordingly.

Follow us on our official WhatsApp channel for breaking news alerts and key updates!
   

Next In World

Russia's claim of emissions in annexed Ukraine regions draws protests at COP29
World leaders split as ICC issues arrest warrant for Netanyahu
Woman wins civil damages claim against MMA star Conor McGregor over rape accusation
North Korea condemns US military drills with South Korea and Japan
Trump taps Scott Bessent for Treasury, capping long drama over choice
Disabled Americans rely on rideshare apps but say they still face discrimination: AP
U.S. private-sector activity picks up pace as firms look forward to new gov't: survey
NYC congestion pricing plan to start in January
Spain's solar power poised to surpass wind power as top renewable energy source
U.S. stocks close higher

Others Also Read